Search results for "Dioscorea villosa"

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Hepatoprotective Effect of Steroidal Glycosides From Dioscorea villosa on Hydrogen Peroxide-Induced Hepatotoxicity in HepG2 Cells

2018

Dioscorea villosa, commonly known as “Wild Yam” and native to North America, is well documented for its pharmacological properties due to the presence of steroidal glycosides. However, the hepatoprotective potential of these compounds has not been studied so far. The present investigation was aimed to study the hepatoprotective effect of the steroidal glycosides from D. villosa against H2O2, a known hepatotoxin, in human liver cell line (HepG2). Cytotoxicity assessment was carried out in cells exposed to various concentrations (10–50 μM) of compounds for 24 h using MTT assay and morphological changes. All tested compounds were known and among them, spirostans (zingiberensis saponin I, diosc…

0301 basic medicineH2O2ProtodioscinSaponinPharmacology03 medical and health scienceschemistry.chemical_compound0302 clinical medicineDioscorea villosaDioscoreaceaePharmacology (medical)MTT assayViability assayCytotoxicityOriginal ResearchPharmacologychemistry.chemical_classificationbiologyChemistrylcsh:RM1-950Hepatotoxinsteroidal glycosidesGlutathionebiology.organism_classificationlcsh:Therapeutics. Pharmacology030104 developmental biologyDioscorea villosa030220 oncology & carcinogenesiscytotoxicityROS generationFrontiers in Pharmacology
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Steroidal saponins and flavan-3-ol glycosides from Dioscorea villosa

2006

chemistry.chemical_classificationchemistrybiologyDioscorea villosaDioscoreaceaeBotanyGlycosideFlavan-3-olbiology.organism_classificationBiochemistryEcology Evolution Behavior and SystematicsBiochemical Systematics and Ecology
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